Rohit Bharat MSc
"Understanding cancer metabolic rewiring has been one of my primary research interests! This project within the EpiPredict network really excites me because it gives me a unique opportunity to exploit high-throughput metabolomics as well as computational modelling techniques to understand the interplay between metabolism and epigenetics, and how in turn could lead to cancer drug resistance."
Early Stage Researcher 7
Name: Rohit Bharat
Gender: Male
Country of Birth: India
MSc in: Medical Biotechnology (Manipal University, India)
Marie Skłodowska Curie PhD Fellowship in Cell/Molecular/BioSciences, University of Milano-Bicocca (UNIMIB), Milan, Italy, in the group of Prof. Lilia Alberghina and Prof. Marco Vanoni, at PhD School of Milano Bicocca
Project: “Identifying metabolic rewiring of endocrine resistance pathways”
Supervisors: PI Prof. Alberghina, Prof. Marco Vanoni, co-supervisor Dr Daniela Gaglio (UNIMIB), EpiPredict co-PI Dr Marcel Ruiters (Synvolux)
Key Objectives & Expected Results
Objectives
- To characterize metabolic profiling in resistance-induced clones
- To test the effect of Metformin to rewire metabolic profiles upon resistance induction
Expected Results
- Insight which metabolic pathways are changed during resistance development
- Identify which mitochondrial fuels underlie resistance development
Host training: Metabolic/proteomic profiling, mass Profiler Professional software, Pathway database searching/discovery
Planned secondment(s): UvA: Data modelling (M5-7), DKFZ: RPPA profiles/patient outcome (M4-5), Synvolux: Protein/DNA delivery (M3)
