EpiPredict>Research>Projects>Development of diagnostic/prognostic DNA methylation tools

Development of diagnostic/prognostic DNA methylation tools

Anchal Nigam MSc

Early Stage Researcher 10
Name: Anchal Nigam
Gender: Female
Country of Birth: India
MSc in: Biochemical Technology (Madurai Kamaraj University, India)

Marie Skłodowska Curie PhD Fellowship in Cell/ Molecular/Medical Biology at the company Epiontis GmbH (Epiontis), Berlin, Germany, supervised by Dr Sven Olek, registered as PhD student at (Charité or) Humboldt-University.

Project: “Development of diagnostic/prognostic DNA methylation tools”

Supervision: PI Dr Sven Olek (Epiontis), the Humboldt or Charité Supervisor will be identified; EpiPredict co-PI Dr Verschure (UvA, NL)

PhD programme: Various graduate schools and programs possible, e.g., Berlin-Brandenburg School of Regenerative Therapies www.bsrt.de

Key Objectives & Expected Results

Objectives

To develop a sensitive DNA methylation detection method for various loci
To test the diagnostic methylation kit on patient samples

Expected Results

Achieve experimental strategies suitable for targeted DNA methylation, possibly CE labelled products
Insight whether DNA methylation interference affects selected resistance genes in resistance-induced clones

Host training: Cell/tissue DNA methylation analyses, product development (R&D).

Planned secondment(s): UvA: Bioinformatics/modelling (M14-15), ICL: Epigenetic profiles (M10-11), MTA-SZBK: DNA methylation interference tools (M21)