Cancer progression and development of resistance to treatment is an urgent medical problem. Mechanistic insight how epigenetic reprogramming as an integral component of lineage-specific transcriptional programmes contributes to controlling cellular decisions provides exciting ways to unravel tumour evolution. The field of epigenetics including chromatin organization, transcription regulation and aspects of stem cell biology offers important insights for cancer biology, individualized patient stratification, monitoring and prediction of treatment outcome, opening-up an unexplored field with great potential for precision medicine.
This conference will bring together scientists from multidisciplinary fields employing different research strategies: (1) Epigenetic profiling at genome-wide and/or single cell level to identify complex dynamic regulatory interactions, (2) Bioinformatics and re-iterative in silico experimentation to predict (dynamic) phenotypic responses upon changes in biological parameters to generate new hypotheses, (3) Innovative epigenetic interference tools using for instance CRISPR/dCas-based epigenetic editing tools to locally overwrite epigenetic signatures and verify the impact of defined alterations in epigenetic regulation.
We aim to create a setting in which links between different disciplines will be emphasized. We will comprehensively discuss processes and mechanisms of various aspects of epigenetic regulation, such as higher order chromatin folding, chromatin enhancer regulation, dynamics of chromatin and nuclear organization and epigenomics specially in the context of cancer progression and treatment. We will touch on latest developments to study epigenetic regulation and set ground for precision medicine in cancer treatment.
The Systems Epigenetics: Precision Cancer Medicine Conference is organized in the context of the ‘EpiPredict’ EU H2020 Innovative training network (www.EpiPredict.eu) coordinated by Dr Pernette Verschure, employing a systems medicine approach to obtain mechanistic, detailed insights in to how epigenetic regulation affects resistance development against hormonal treatment in breast cancer estrogen receptor positive patients.
More information will follow soon...